The treatment of chronic pyelonephritis principle

Conventional Western medicine treatment:
As acute pyelonephritis over six months to change that is not cured of chronic, it should be early and complete treatment because of chronic pyelonephritis repeated attack, causing inflammation of the kidneys and repair of the turn, connective tissue proliferation and scar formation, making local blood Win poor, not easy access to antibiotics lesions; local poor drainage, difficult to remove bacteria, inflammation Nankong Zhi, impaired renal difficult to repair. And the resumption of kidney damage before the infection is caused repeated an important factor. Hence the treatment of chronic pyelonephritis focus on the eradication of bacteria as soon as possible, to resume as soon as possible kidney damage. At the same time actively seeking susceptible, and eliminate or avoid, such as urinary tract stones, deformities, benign prostatic hyperplasia, pelvis and the perineum, Gan Ranzao, and so is the premise of effective antibiotic treatment. The principle of antibiotic therapy are as follows:
1, should focus on pathogens and susceptibility choose effective drugs, drugs should be carefully screened to observe the effects. Regular urine culture and colony counting and the results of testing for susceptibility to choose the most sensitive to antibiotics. For the reasons for urinary tract obstruction and infection, should be promptly ruled out for causes and treatment.
2, the rule is more stubborn bacteria, the general use of antibacterial drugs combined methods, such as SMZ + TMP, furans Dan啶plus gentamicin can choose norfloxacin, carboxymethyl benzylpenicillin, tobramycin, Pioneer will, General treatment for two weeks, the interval for the next 5-7 days after treatment. Until the urine routine training and the time of conversion. Total treatment sometimes takes 2-4 months. Treatment must be sufficient, if not full course of treatment, even if the treatment is effective but not completely eliminate pathogens, but also developed a resistance to bacteria in the remnant, once the conditions for, and relapse, protracted illness. So acute chronic pyelonephritis, according to the treatment of acute pyelonephritis principles of medication, the treatment of not less than four weeks. When all the clinical symptoms were controlled, to observe the withdrawal, a monthly review of conventional urine and urine culture, generally for about six months. In antimicrobial therapy is invalid, the available antimicrobial therapy. Specific methods: emptying the bladder before going to bed every night after serving two sulfamethoxazole (or furan Dan啶0.1 g; naphthalene啶acid 0.5 g; Norfloxacin 0.2 g) for 3-6 months, about 60 percent of patients with culture May be negative. This method of time-consuming, should pay attention to drug side effects.


Nano infiltration of Chinese medicine therapy
According to cause kidney damage to the immune lead to kidney damage and blood perfusion of the primary obstacles of various kinds of secondary and kidney disease have a unique effect on the treatment of the pyelonephritis role and function points are as follows:
1, immune to the kidney injury in principle
Duplex regulation of the immune function
After the use of nanotechnology is extremely immune activity of the properties in conjunction with the specific targeting of its location and focus on the affinity of the characteristics of traditional Chinese medicine into the active substance in the body, targeted activation of the immune function of the lower the patient's immune system, antibodies to Generation, while the surplus of patients selective immune suppression hyperthyroidism stress its status to a state of disorder tend to balance reducing the immune-mediated inflammatory mediators continue to damage the kidneys. Reduce mesangial cell proliferation, glomerular continue to slow down the rate of hardening and restore damaged functions, improve the state of the body, increase resistance capacity.
Selective Targeting located in the kidney lesions, the elimination of immune complex features:
Nano-strong immune activity after the traditional Chinese medicine substances into the body, rapid positioning in the deposition of immune complex lesions, a role the following: (1) First and deposition of immune complex lesions and integration, (2 ) The effective integration, re-gathered for the new elements and changed the cellular and molecular structure of the bond and prompt release of drug ingredients to attack. (3) immune complexes, and kidney lesions in the active pharmaceutical ingredients under attack rapidly dividing, disintegrating, broken, scattered debris from the removal of the following ways. (1) activation of phagocytes, the attack shattered swallowed up by larger debris. (2) the remaining small and medium-sized members were out in excretion and metabolism.
This is Nano after removal of traditional Chinese medicine substances Huayu immune complexes and the main way to repair damaged kidneys organizations laid the foundation.
2, against obstacles lead to kidney blood flow in the role of principle
Huoxue Tongluo, improve microcirculation:
(1) after the nano-material selective targeting of Chinese medicine in the autonomic positioning system and the promotion of kidney tissue of the prostate secretion, and the general expansion of the renal arteries, kidney damage and improve the general microcirculation.
(2) to improve the gastrointestinal mucosa microcirculation and reduce mucosal edema, to digestive juice production, enhance patient appetite.
(3) to promote peripheral vascular expansion, improve skin microcirculation, and promote open porokeratosis of toxins from the sweat.
Expansion of the renal artery to increase blood perfusion effective kidney damage, increase the oxygen supply to the kidneys and improving kidney microcirculation and reduce pressure within the glomeruli and promote glomerular repair damaged lesions change the organizational structure, functional recovery.
Nano-medicine treatment of active substances kidney disease, uremia of the three treatment process and its pathology, pathophysiology, clinical changes.
The first process: Huoxue Tongluo, the oxygen supply to the kidney lesions, improve microcirculation and reduce pressure within the glomeruli process (lower pressure within the glomeruli stage)
Into the kidney after the nano-medicine substances have the following effects: ① first selective targeting targeted at all levels in kidney damage arteries, and its close integration; ② renal artery to expand and increase blood perfusion kidney effectively increase Glomerular damage to the oxygen supply, improve microcirculation and increase metabolism, reduce glomerular pressure, reduce the glomerular hyperfiltration state. ③ delay the progress of disease.
1, if the steps after the completion of its renal hemodynamics, we can ease the glomerular high infusion of high pressure will ease the glomeruli; will ease the high filtration state glomerulosclerosis and stop delaying the process.
2, if the stage after the completion of its clinical manifestations: ① urine protein and occult blood start to fall; ② urine creatinine begin to increase; ③ serum creatinine started to decline; ④ renal hypertension, and gradually ease; ⑤ ease the symptoms of systemic poisoning, such as weak Reduce, vomiting disappeared, appetite increase, and so began sweating; ⑥ the rise of urine, urine color and turbidity and the smell will change.
The second process: Quyu to remove kidney lesions and immune complex process (removal of lesions stage)
Selective targeting of nano-positioning of the Chinese medicine substances, in the expansion of the renal artery, increasing oxygen supply, improve microcirculation of the premise, and the disease-specific immune complex organizations and close integration, the focus of attacks Sudden outbreak, will be immune complex and the proliferation of the cell membrane, the matrix, glomerular sclerosis, and other lesions gradually completely smashed, cracking, finally broken down into small fragments, with the blood circulation, or swallowed up by the phagocytes metabolism, excretion, etc. . At the same time nano-active material on the Chinese invasion of the kidney in the immune complex disease before they had not yet eliminated them, and timely release of the body to effectively trace the material, to improve the health status of patients.
The process of clinical features:
Clinical symptoms gradually improved, indicators of stability tests, gradually stable condition, as long as not susceptible factors, the process, in particular clearance will continue to play a lasting.
The third process: the new Health, the lesions of the restoration and reconstruction process (repair and reconstruction phase)
Repair at the following three steps:
1, selective targeting of positioning:
Nano-medicine substances, the glomerular filtration membrane repair: First activation of the cell membrane, to prevent their proliferation; inhibiting collagen GBM cell activity progress, the restoration of the basement membrane fracture (fracture of nano-medicine and its elements are linked Strong affinity) to increase the mechanical barrier filtration area and resume a normal permeability.
2, the restoration of the basement membrane charge barrier:
Nano after the rupture of molecular medicine substances have strong links with the basement membrane fusion, fracture of the molecular chain with positive charge and impairment of cellular and molecular bond prices after stabilized again, its effectiveness is the promotion of Basement membrane on the type of heparin sulfate and sialic acid protein synthesis and inhibit their decomposition, thereby maintaining a negative charge basement membrane barrier, to reduce the leakage of protein, increasing the toxin from. Nano-medicine after the restoration of the active substance is the basement membrane charge barriers, and restore the basement membrane of the selective filtering function.
3, reorganization and reconstruction of the mechanisms involved in glomerular repair:
Nano and the other after the fracture between the molecular chain reorganization, have a new function, and impaired kidney cells in the imperfections of the molecular chain of combining to form the new elements, the cellular and molecular changes in the price - Structure, repair damaged cells in DNA, blood at the same time to accelerate and enhance the metabolism, the key is activated cell damage mechanism of DNA replication. Promote impaired renal cell repair and regeneration, to damage reconstruction. Structural changes in kidney damage, impaired renal function gradually resumed.
The main features of the stage: Huoxue Tongluo (oxygen hypotension), Huayu (clear), the new Health (repair and reconstruction of) the three key steps to repair, structural changes, the renal function can gradually resume, clinical Symptoms can turn for the better. But restoration is a long process, so adhere to treatment is fundamental and lasting restoration after the kidney is extremely resistant ability, once the repair in place, the disease will not be attacked, the more will not relapse again.