Lupus nephritis can lead to kidney syndrome

SLE is a systemic violations of the autoimmune connective tissue disease, involving multi-system disease, multiple organ. SLE lupus nephritis is the most common damage to internal organs, in patients diagnosed with systemic lupus erythematosus, about 70 percent have significant kidney damage, such as a biopsy is almost 100 percent of the patients had kidney damage pathological changes, the kidney The severity of the disease directly affect the patient's prognosis.

The pathogenesis of the disease is extremely complex, but now recognized as an immune complex-mediated nephritis. The main mechanism should include the incidence of anti-DNA antibodies and immune complexes induced glomerular injury, B cells to produce a pathogenic role in the anti-DNA antibodies, the helper T cells involved in B cell activation, the number of core body or unusual small nuclear Physical. In recent years, LN the incidence of the rising trend in China is about 8/10000. The disease occurs in young women, the incidence of male to female ratio is about 1:9, younger, more severe illness may be, the worse the prognosis, especially male patients.

Lupus nephritis kidney damage can be the performance of the performance of glomerulonephritis, may also be the performance of nephrotic syndrome, the clinical diagnosis of kidney must rule out the possibility of lupus nephritis.