4/22/08

Why Tuberculosis(TB) Chemotherapy Fail

Application of standard chemotherapy or short-course chemotherapy in the treatment of tuberculosis, the success rate could reach 100 percent, but in practice the failure rate remains high, mainly because of the following reasons:

1, chemotherapy unreasonable, neither of programmes combination of drugs, nor reasonable dose of drug, the drug did not complete the course of treatment, which was mainly due to individual medical staff not familiar with the treatment of tuberculosis, just be satisfied with habits medication.

2, it is not timely drug treatment of the most common causes of failure, or about 40 per cent. Especially when told patients their medication common. Due to poor management, coupled with the patient's unconscious, not quite多见medication on time. Experts have pointed out that: Experts have pointed out that: the success of a reasonable efficacy = + effective chemotherapy for the organization and management, pointed out that the management in the importance of TB treatment. It can be said that, without strict management, there can be no successful chemotherapy.

3, premature cessation of medication, which is also a common causes of the failure, or about 36%, this may be due to unclear doctors explain, the patient transfer or abandon their treatment, since that illness, abandon the treatment.

4, drug toxicity, mainly due to anti-TB drugs on liver function damage and various allergies, the treatment of complicated, abnormal liver function, many anti-tuberculosis drugs to stop the use of those who are allergic to desensitization, in a very long time, can only use a medicine, then the resistance is likely to occur.

5, the primary drug resistant infections, without sensitivity test, the administration blindly, as the original TB drug resistance caused by the failure of treatment.

6. Atypical AFB infections, tuberculosis and atypical acid-fast bacilli are very similar, all of which have acid, bacteria often violations of the lungs, caused by Mycobacterium tuberculosis and difficult to distinguish, in patients with pulmonary tuberculosis is atypical by acid-fast bacilli to the domestic information atypical acid-fast bacilli accounted for 4.4 percent of these patients with anti-TB drugs are often poor or ineffective results.

To sum up, resulting in chemotherapy is not the main reason for the failure to tuberculosis hospital treatment or not

Therefore King advised overwhelming majority of patients, if you have a clear suspect or suffering from tuberculosis, to go to a hospital for treatment of tuberculosis, the Siping City Hospital diagnosed tuberculosis chemotherapy and force, effective and thorough treatment, TB is the nemesis.

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